Solution structure of the antifreeze-like domain of human sialic acid synthase.
نویسندگان
چکیده
The structure of the C-terminal antifreeze-like (AFL) domain of human sialic acid synthase was determined by NMR spectroscopy. The structure comprises one alpha- and two single-turn 3(10)-helices and two beta-strands, and is similar to those of the type III antifreeze proteins. Evolutionary trace analyses of the type III antifreeze protein family suggested that the class-specific residues in the human and bacterial AFL domains are important for their substrate binding, while the class-specific residues of the fish antifreeze proteins are gathered on the ice-binding surface.
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عنوان ژورنال:
- Protein science : a publication of the Protein Society
دوره 15 5 شماره
صفحات -
تاریخ انتشار 2006